What I do know is that they show up at my office still looking for an answer. Their treatment histories are full of information on a variety of medications that have been tried with little to no success. Common meds include stimulants (Adderall), tranquilizers (Benzodiazepines), various anti-psychotics and anti-epileptics. Most have developed a history psychoactive substance use and abuse. Many seem to be hypersensitive to SSRI's and report significant and negative effects when they've been tried. Some report that small amounts of cocaine seem to make them feel human for once and most call Starbucks or Caribou Coffee their home away from home.
In a nutshell they appear to show a good deal of sensitivity to any substance that alters the biochemistry or neurochemistry of their neurotransmitters and neurotransmission. All report that their natural physical state is one of discomfort and agitation and all report that various substances whether prescribed or used illicitly remove the discomfort in the exact same way that aspirin removes the pain of a headache. Unfortunately it is this type of reinforcement paradigm that forms the basis for much of the substance dependence we see today.
For the parents of these kids, even in the best of cases, it's a wild and highly stressful ride. Just about any impulsive behavior is possible and often becomes a reality. Even with constant mental health care, nightmare outcomes are possible. From a treatment point of view there is not much in the way of Evidence Based Treatments.
Time will tell if growing out of it is a common outcome but until then the parents of these kids live a nightmare and the kids themselves continue to search for a chemical answer that does not contain a downside as far as personal alienation, arrest, dependence and abuse or other negative result.